Description

4-Chloro-3-Fluoro-2-Formylphenylboronic Acid is a high-value, multi-functional boronic acid derivative featuring both formyl and halogen substituents on the aromatic ring. This unique structure makes it a critical advanced pharmaceutical intermediate and a versatile Suzuki-Miyaura cross-coupling building block for constructing complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to introduce functionalized biaryl motifs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific halogenated biaryl structures.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group enables efficient palladium-catalyzed carbon-carbon bond formation with aryl halides.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology Probes: Useful for synthesizing tagged molecules for studying biological pathways and protein interactions.

Basic Information

Product Name	4-Chloro-3-Fluoro-2-Formylphenylboronic Acid
CAS No.	1451392-90-7
Molecular Formula	C7H5BClFO3
Molecular Weight	201.38 g/mol
Synonyms	2-Formyl-4-chloro-3-fluorophenylboronic acid; (4-Chloro-3-fluoro-2-formylphenyl)boronic acid; 4-Chloro-3-fluoro-2-formylbenzeneboronic acid; Boronic acid, B-(4-chloro-3-fluoro-2-formylphenyl)-; 1451392-90-7
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoro-2-Formylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.