Description

2-Bromo-3-Chloro-6-Fluorophenylboronic Acid is a high-purity, multi-halogenated boronic acid derivative serving as a critical building block in modern synthetic chemistry. Its value lies in enabling precise cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex molecular architectures efficiently. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly in the development of active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially in constructing complex biaryl and heterobiaryl structures central to many therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides that require specific halogenated aromatic frameworks.
• Material Science: Building block for creating organic electronic materials, including monomers for conductive polymers and organic light-emitting diodes (OLEDs).
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for methodology development and exploring new chemical spaces via palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry programs.

Basic Information

Product Name	2-Bromo-3-Chloro-6-Fluorophenylboronic Acid
CAS No.	1451392-82-7
Molecular Formula	C6H4BBrClFO2
Molecular Weight	253.26 g/mol
Synonyms	(2-Bromo-3-chloro-6-fluorophenyl)boronic acid; 2-Bromo-3-chloro-6-fluorobenzeneboronic acid; B-(2-Bromo-3-chloro-6-fluorophenyl)boronic acid; 1451392-82-7; Boronic acid, B-(2-bromo-3-chloro-6-fluorophenyl)-; AKOS026710793; FT-0773297
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Chloro-6-Fluorophenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency. Our quality control protocols include advanced chromatographic and spectroscopic methods to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific impurity limits is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.