Description

6-Fluoro-2-(Methylsulfanyl)Phenylboronic Acid CAS NO 1451392-58-7 is a high-purity, synthetically valuable organoboron compound featuring both fluorine and methylthio substituents on the aromatic ring. This unique structure makes it a critical building block in modern cross-coupling reactions, such as the Suzuki-Miyaura reaction, enabling the efficient synthesis of complex biaryl systems. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring fluorinated and sulfur-containing motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorine atom and thioether group contribute to biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or building block for developing advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds, constructing complex molecular architectures for various R&D applications.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale commercial batches.

Basic Information

Item	Details
Product Name	6-Fluoro-2-(Methylsulfanyl)Phenylboronic Acid
CAS No.	1451392-58-7
Molecular Formula	C7H8BFO2S
Molecular Weight	185.99 g/mol
Synonyms	2-Fluoro-6-(Methylthio)Benzeneboronic Acid; (6-Fluoro-2-(Methylthio)Phenyl)Boronic Acid; 6-Fluoro-2-(Methylsulfanyl)Benzeneboronic Acid; 6-Fluoro-2-(Methylmercapto)Phenylboronic Acid; 2-(Methylthio)-6-Fluorophenylboronic Acid; Boronic acid, B-[6-fluoro-2-(methylthio)phenyl]-; 1451392-58-7
EINECS	Contact for details

Quality Control

Our 6-Fluoro-2-(Methylsulfanyl)Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.