Description

2,6-Difluoro-3-(Methylthio)Phenylboronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in modern herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials where the difluoro and methylthio groups modulate electronic properties.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a versatile boronic acid coupling partner with various aryl/heteroaryl halides or triflates to form biaryl and heterobiaryl linkages under palladium catalysis.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of fine chemicals and complex organic molecules.

Basic Information

Product Name	2,6-Difluoro-3-(Methylthio)Phenylboronic Acid
CAS No.	1451392-56-5
Molecular Formula	C7H7BF2O2S
Molecular Weight	203.99 g/mol
Synonyms	(2,6-Difluoro-3-(methylthio)phenyl)boronic acid; 3-Methylthio-2,6-difluorophenylboronic acid; 2,6-Difluoro-3-methylsulfanylbenzeneboronic acid; B-(2,6-Difluoro-3-methylsulfanylphenyl)boronic acid; 2,6-Difluoro-3-(methylmercapto)phenylboronic acid; 2,6-Difluoro-3-(methylthio)benzeneboronic acid; 1451392-56-5
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-3-(Methylthio)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH guidelines, and other relevant regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5% w/w
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.