Description

5-Fluoro-2-(Morpholinomethyl)Phenylboronic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block for organic synthesis. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl halides and boronic acids, essential for constructing drug-like molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugates for target identification and binding studies.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses producing specialized compounds for client R&D programs.

Basic Information

Product Name	5-Fluoro-2-(Morpholinomethyl)Phenylboronic Acid Hydrochloride
CAS No.	1451391-80-2
Molecular Formula	C11H15BFNO3 • HCl
Molecular Weight	287.51 g/mol (Free base: 251.05 g/mol)
Synonyms	[2-(Morpholinomethyl)-5-fluorophenyl]boronic acid hydrochloride; 5-Fluoro-2-(morpholin-4-ylmethyl)phenylboronic acid HCl; (5-Fluoro-2-((morpholinomethyl)phenyl)boronic acid hydrochloride; Boronic acid, B-[5-fluoro-2-[(4-morpholinyl)methyl]phenyl]-, hydrochloride (1:1); CAS 1451391-80-2
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(Morpholinomethyl)Phenylboronic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.