Description

4-Bromo-2-Fluorophenylboronic Acid n-Butyldiethanolamine Ester is a specialized, protected boronic acid derivative designed for advanced organic synthesis. This compound matters because the n-butyldiethanolamine ester group significantly enhances its stability, handling, and solubility compared to the free boronic acid, making it a superior reagent for sensitive cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in Suzuki-Miyaura couplings.

Application

• Pharmaceutical Intermediate Synthesis: A key building block in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require the specific 4-bromo-2-fluorophenyl moiety.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is critical.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and bioconjugation reagents due to its selective reactivity.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	4-Bromo-2-Fluorophenylboronic Acid n-Butyldiethanolamine Ester
CAS No.	1451391-63-1
Molecular Formula	C₁₄H₂₀BBrFNO₂
Molecular Weight	360.03 g/mol
Synonyms	4-Bromo-2-fluorobenzeneboronic acid N,N-dibutyl-2,2'-iminodiethanol ester; 2-Fluoro-4-bromophenylboronic acid diethanolamine butyl ester; B-(4-Bromo-2-fluorophenyl)-N,N-bis(2-hydroxyethyl)-N-butylborinic amide ester; N-Butyldiethanolamine 4-Bromo-2-fluorobenzeneboronate; Boronic acid, B-(4-bromo-2-fluorophenyl)-, N,N-bis(2-hydroxyethyl)-N-butyl ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluorophenylboronic Acid n-Butyldiethanolamine Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.