Description

6-Fluoro-2-Hydroxy-3-Methylphenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is essential as a key building block in modern cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing complex biaryl or heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require the introduction of specific fluorinated phenolic motifs.
• Material Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials with tailored properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems and enzyme activity.
• Process Chemistry & Scale-up: Utilized in route scouting and optimization for the commercial-scale production of fine chemicals and active pharmaceutical ingredients (APIs).
• Academic & Contract Research: A valuable reagent for methodological development in organic synthesis and for producing target molecules in contract research organizations (CROs).

Basic Information

Product Name	6-Fluoro-2-Hydroxy-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	1451391-55-1
Molecular Formula	C₁₃H₁₈BFO₃
Molecular Weight	252.09 g/mol
Synonyms	(6-Fluoro-2-hydroxy-3-methylphenyl)boronic acid pinacol ester; 2-(6-Fluoro-2-hydroxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-Fluoro-2-hydroxy-3-methylbenzeneboronic acid pinacol ester; Pinacol (6-Fluoro-2-hydroxy-3-methylphenyl)boronate; Boronic acid, B-(6-fluoro-2-hydroxy-3-methylphenyl)-, 1,1-dimethylethyl ester (9CI); 6-Fluoro-3-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; Fluorohydroxymethylphenylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 6-Fluoro-2-Hydroxy-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed under an inert atmosphere to maximize shelf-life stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.