Description

3-Fluoro-2-Formyl-4-Methylphenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a formyl and a boronic acid group on a fluorinated aromatic ring, makes it an indispensable reagent for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced cross-coupling and functional group transformation reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and infectious diseases via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atom and boronic acid group enable the introduction of specific bioactive motifs.
• Material Science Research: Serves as a monomer or linker in the creation of advanced organic frameworks, polymers, and liquid crystals with tailored electronic or optical properties.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and sensors for studying biological processes, leveraging its ability to form stable bonds with diols and other functional groups.
• Catalyst Ligand Preparation: Utilized to synthesize novel bidentate or tridentate ligands for transition metal catalysts used in asymmetric synthesis.

Basic Information

Product Name	3-Fluoro-2-Formyl-4-Methylphenylboronic Acid
CAS No.	1451391-40-4
Molecular Formula	C8H8BFO3
Molecular Weight	181.96 g/mol
Synonyms	(3-Fluoro-2-formyl-4-methylphenyl)boronic acid; 2-Borono-3-fluoro-4-methylbenzaldehyde; 3-Fluoro-4-methyl-2-formylbenzeneboronic acid; 3-Fluoro-2-formyl-p-tolylboronic acid; 2-Formyl-3-fluoro-4-methylbenzeneboronic acid; Boronic acid, B-(3-fluoro-2-formyl-4-methylphenyl)-; 1451391-40-4
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-2-Formyl-4-Methylphenylboronic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity requirements suitable for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and spectroscopic data. We support custom synthesis and can tailor specifications to meet specific project needs, including compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to prevent decomposition. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.