Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethoxy)Benzenamine is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester and a trifluoromethoxy-substituted aniline moiety. This compound is critical for enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring the trifluoromethoxy group for metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the specific substitution pattern confers desired biological activity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular engineering is required.
• Chemical Biology & Probe Development: Acts as a precursor for creating molecular probes and tags used in biochemical assays and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethoxy)Benzenamine
CAS No.	1451391-22-2
Molecular Formula	C13H17BF3NO3
Molecular Weight	303.09 g/mol
Synonyms	4-(Trifluoromethoxy)phenylboronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)aniline; 4-(Trifluoromethoxy)aniline-2-boronic acid pinacol ester; 4-Amino-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl trifluoromethyl ether; 2-Amino-5-(trifluoromethoxy)phenylboronic acid pinacol ester; [2-Amino-5-(trifluoromethoxy)phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethoxy)Benzenamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.