Description

4-Bromo-3-Fluorophenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery, catalyst development, and the synthesis of functional organic molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl halides and boronic acids, fundamental in constructing biaryl structures found in many active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly those requiring halogenated, fluorinated aromatic scaffolds.
• Agrochemical Compound Development: Employed in creating advanced herbicides, fungicides, and insecticides that benefit from the specific properties of the bromo-fluoro-phenyl moiety.
• Ligand and Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands used in homogeneous catalysis and material science applications.
• Organic Electronic Materials: Useful in the synthesis of conjugated polymers and small molecules for OLEDs, OFETs, and other optoelectronic devices.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Serves as a versatile linker or building block in the design of bifunctional molecules for targeted protein degradation.

Basic Information

Product Name	4-Bromo-3-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1451391-19-7
Molecular Formula	C₁₂H₁₅BBrFO₂
Molecular Weight	301.96 g/mol
Synonyms	4-Bromo-3-fluorobenzeneboronic acid pinacol ester; (4-Bromo-3-fluorophenyl)boronic acid pinacol ester; 2-(4-Bromo-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (4-Bromo-3-fluorophenyl)boronate; 4-Bromo-3-fluoro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; B-(4-Bromo-3-fluorophenyl)boronic acid pinacol ester; Boronic acid, B-(4-bromo-3-fluorophenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality management system is designed to meet the stringent requirements of research and development as well as scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Purity (NMR)	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.