Description

6-Bromo-3-Chloro-2-Fluorophenylboronic Acid Pinacol Ester CAS NO 1451391-14-2 is a high-purity, multi-halogenated boronic ester building block essential for modern synthetic chemistry. Its value lies in enabling precise cross-coupling reactions, such as Suzuki-Miyaura couplings, to construct complex molecular architectures with high efficiency and selectivity. This advanced intermediate is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the specific halogen pattern can influence bioactivity.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, and polymers with tailored properties.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to form new carbon-carbon bonds, a cornerstone reaction in complex molecule assembly.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated boronic esters.

Basic Information

Item	Details
Product Name	6-Bromo-3-Chloro-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1451391-14-2
Molecular Formula	C12H14BBrClFO2
Molecular Weight	349.41 g/mol
Synonyms	6-Bromo-3-chloro-2-fluorophenylboronic acid pinacol ester; (6-Bromo-3-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Bromo-5-chloro-6-fluorophenylboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(6-bromo-3-chloro-2-fluorophenyl)-1,3,2-dioxaborolane; Boronic acid, B-(6-bromo-3-chloro-2-fluorophenyl)-, 1,1-dimethylethyl ester (9CI); Pinacol (6-Bromo-3-chloro-2-fluorophenyl)boronate
EINECS	Contact for details

Quality Control

Every batch of our 6-Bromo-3-Chloro-2-Fluorophenylboronic Acid Pinacol Ester undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for advanced synthetic applications. We employ techniques including HPLC, GC, NMR, and mass spectrometry to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all relevant specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.