Description

5-Bromo-2-Fluoro-3-Formylphenylboronic Acid, Pinacol Ester is a high-value, multi-functional boronic ester derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its molecular architecture, featuring bromo, fluoro, and formyl substituents on a boronic ester core, makes it an indispensable building block for constructing complex molecules with precise electronic and steric properties. This compound is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications such as Suzuki-Miyaura cross-coupling and further functional group transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation, where the halogen and aldehyde groups allow for sequential derivatization.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides, leveraging its structural motifs to fine-tune biological activity and environmental stability.
• Material Science & OLED Development: Used as a building block for creating organic semiconductors, liquid crystals, and light-emitting materials for organic light-emitting diodes (OLEDs) due to its electron-deficient aromatic system.
• Suzuki-Miyaura Cross-Coupling Reactions: Functions as a stable, air-handleable organoboron reagent for palladium-catalyzed cross-coupling to form biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Chemical Biology & Probe Development: Serves as a versatile scaffold for synthesizing molecular probes and inhibitors used in biochemical assays and target identification studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs producing bespoke compounds for client research programs.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-Formylphenylboronic Acid, Pinacol Ester
CAS No.	1451391-13-1
Molecular Formula	C13H15BBrFO3
Molecular Weight	329.97 g/mol
Synonyms	(5-Bromo-2-fluoro-3-formylphenyl)boronic acid pinacol ester; 2-Bromo-6-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; 5-Bromo-2-fluoro-3-formylbenzeneboronic acid pinacol ester; 3-Bromo-6-formyl-2-fluorophenylboronic acid pinacol ester; Pinacol (5-Bromo-2-fluoro-3-formylphenyl)boronate; Boronic acid, B-(5-bromo-2-fluoro-3-formylphenyl)-, 1,1-dimethylethyl ester (9CI); CAS 1451391-13-1
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Fluoro-3-Formylphenylboronic Acid, Pinacol Ester is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential decomposition. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.