Description

3-Bromo-6-Chloro-2-Fluorophenylboronic Acid Pinacol Ester is a high-purity, multi-halogenated boronic ester building block essential for modern synthetic chemistry. Its value lies in its stability and versatility as a key intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. This compound is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used to construct complex heterocyclic scaffolds found in advanced herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic applications.
• Catalyst Ligand Development: Provides a halogenated aromatic core for the design and synthesis of novel organometallic catalyst ligands.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for bespoke synthesis projects requiring specific halogenated boronic esters.

Basic Information

Item	Details
Product Name	3-Bromo-6-Chloro-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	1451391-12-0
Molecular Formula	C12H14BBrClFO2
Molecular Weight	349.41 g/mol
Synonyms	(3-Bromo-6-chloro-2-fluorophenyl)boronic acid pinacol ester; 2-(3-Bromo-6-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-6-chloro-2-fluorobenzeneboronic acid pinacol ester; Pinacol (3-bromo-6-chloro-2-fluorophenyl)boronate; Boronic acid, B-(3-bromo-6-chloro-2-fluorophenyl)-, 1,1-dimethylethyl ester; 3-Bromo-6-chloro-2-fluoro phenylboronic acid pinacol ester; CAS 1451391-12-0
EINECS	Contact for details

Quality Control

Our 3-Bromo-6-Chloro-2-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.