Description

3-Bromo-5-Chloro-2,6-Difluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern organic synthesis for forming carbon-carbon bonds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex, multi-halogenated biphenyl or heterobiaryl cores.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific halogenated aromatic motifs for bioactivity.
• Material Science Research: Serves as a precursor for developing organic electronic materials, such as ligands for OLEDs or molecular wires, where the halogen and boron functionalities allow for further derivatization.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis or as a scaffold for boron-based catalyst systems.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or bioconjugates for proteomics and diagnostic assay development.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector, enabling the production of bespoke compounds for client projects.

Basic Information

Product Name	3-Bromo-5-Chloro-2,6-Difluorophenylboronic Acid Pinacol Ester
CAS No.	1451391-11-9
Molecular Formula	C12H13BBrClF2O2
Molecular Weight	353.40 g/mol
Synonyms	(3-Bromo-5-chloro-2,6-difluorophenyl)boronic acid pinacol ester; 2-(3-Bromo-5-chloro-2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-5-chloro-2,6-difluorobenzeneboronic acid pinacol ester; Pinacol (3-bromo-5-chloro-2,6-difluorophenyl)boronate; B-(3-Bromo-5-chloro-2,6-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-(3-bromo-5-chloro-2,6-difluorophenyl)-, 1,1-dimethylethyl ester (9CI); 1451391-11-9
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chloro-2,6-Difluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure high chemical purity and structural integrity, critical for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profiles are available upon request and are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.