Description

2-Chloro-6-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron reagent, specifically a protected boronic acid derivative. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures in modern organic synthesis. It is a critical building block for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, enabling the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex aryl-aryl linkages.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific halogenated and fluorinated aromatic motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is crucial.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the construction of molecular probes and tags for studying biological systems and drug discovery.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences sector.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester
CAS No.	1451391-09-5
Molecular Formula	C₁₃H₁₅BClF₃O₂
Molecular Weight	306.52 g/mol
Synonyms	2-Chloro-6-(trifluoromethyl)benzeneboronic acid pinacol ester; [2-Chloro-6-(trifluoromethyl)phenyl]boronic acid pinacol ester; 2-Chloro-α,α,α-trifluoro-m-tolylboronic acid pinacol ester; (2-Chloro-6-(trifluoromethyl)phenyl)boronic acid pinacol ester; Pinacol 2-chloro-6-(trifluoromethyl)phenylboronate; B-[2-Chloro-6-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Trifluoromethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥97% (by HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.