Description

2,4-Difluoro-3-isopropoxyphenylboronic acid is a high-purity boronic acid derivative featuring a difluorinated and isopropoxy-substituted aromatic ring. This compound is a critical building block in modern organic synthesis, valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the construction of complex, fluorinated biaryl structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated biphenyl or heterobiaryl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms improves efficacy and environmental profile.
• Material Science Research: Used in the development of organic electronic materials, such as ligands for catalysts or monomers for specialty polymers, where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron reagent for forming carbon-carbon bonds between aromatic rings, a fundamental transformation in medicinal and process chemistry.
• Chemical Biology & Probe Development: Utilized in creating molecular probes and diagnostic agents that leverage the specific reactivity of the boronic acid functional group.

Basic Information

Product Name	2,4-Difluoro-3-isopropoxyphenylboronic Acid
CAS No.	1451390-95-6
Molecular Formula	C9H11BF2O3
Molecular Weight	216.00 g/mol
Synonyms	(2,4-Difluoro-3-isopropoxyphenyl)boronic acid; 3-Isopropoxy-2,4-difluorophenylboronic acid; 2,4-Difluoro-3-(1-methylethoxy)benzeneboronic acid; Boronic acid, B-(2,4-difluoro-3-isopropoxyphenyl)-; 1451390-95-6; 2,4-Difluoro-3-isopropoxybenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-isopropoxyphenylboronic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, well-ventilated place. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.