Description

4-Fluoro-3-Isopropoxyphenylboronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex fluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that benefit from the unique properties of the fluorinated aromatic system.
• Material Science Research: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a boronic acid coupling partner with aryl/vinyl halides or triflates to form carbon-carbon bonds under palladium catalysis.
• Chemical Biology & Probe Development: Utilized in the design and synthesis of molecular probes and diagnostic agents for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	4-Fluoro-3-Isopropoxyphenylboronic Acid
CAS No.	1451390-94-5
Molecular Formula	C9H12BFO3
Molecular Weight	198.00 g/mol
Synonyms	(4-Fluoro-3-isopropoxyphenyl)boronic acid; 3-Isopropoxy-4-fluorophenylboronic acid; 4-Fluoro-3-(1-methylethoxy)benzeneboronic acid; Boronic acid, B-(4-fluoro-3-isopropoxyphenyl)-; 1451390-94-5; 4-Fluoro-3-isopropoxybenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Isopropoxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability, as boronic acids can be moisture-sensitive.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.