Description

3,5-Difluoro-4-isopropoxyphenylboronic acid is a high-purity boronic acid derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex difluorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile boronic acid reagent for palladium-catalyzed C-C bond formation with aryl halides.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in lead optimization and route scouting for new chemical entities.
• Ligand Synthesis: Can be utilized to create sophisticated ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	3,5-Difluoro-4-isopropoxyphenylboronic Acid
CAS No.	1451390-93-4
Molecular Formula	C9H11BF2O3
Molecular Weight	216.00 g/mol
Synonyms	(3,5-Difluoro-4-isopropoxyphenyl)boronic acid; B-(3,5-Difluoro-4-isopropoxyphenyl)boronic acid; 4-Isopropoxy-3,5-difluorophenylboronic acid; 3,5-Difluoro-4-(1-methylethoxy)benzeneboronic acid; 3,5-Difluoro-4-propan-2-yloxybenzeneboronic acid; 1451390-93-4; Boronic acid, B-[3,5-difluoro-4-(1-methylethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-isopropoxyphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.