Description

3-Acetyl-2,6-Difluorophenylboronic Acid is a high-value boronic acid derivative characterized by its acetyl and difluoro substituents, which are critical for fine-tuning reactivity and electronic properties in advanced synthesis. This compound serves as a versatile and essential building block in modern pharmaceutical and agrochemical research, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Employed in the research and development of new generation herbicides, fungicides, and insecticides, where the difluorophenyl moiety enhances biological activity and metabolic stability.
• Material Science Research: Used in the development of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics, where precise molecular engineering is required.
• Ligand and Catalyst Development: Serves as a starting material for creating novel bidentate ligands and organometallic catalysts used in asymmetric synthesis and other specialized catalytic processes.
• Chemical Biology Probes: Utilized in the construction of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global pharmaceutical and biotechnology industries.

Basic Information

Product Name	3-Acetyl-2,6-Difluorophenylboronic Acid
CAS No.	1451390-81-0
Molecular Formula	C8H7BF2O3
Molecular Weight	199.95 g/mol
Synonyms	(3-Acetyl-2,6-difluorophenyl)boronic acid; 2,6-Difluoro-3-acetylbenzeneboronic acid; 3-Acetyl-2,6-difluorobenzeneboronic acid; Boronic acid, B-(3-acetyl-2,6-difluorophenyl)-; 1451390-81-0; 3-Acetyl-2,6-difluorophenyl-B(OH)2
EINECS	Contact for details

Quality Control

Every batch of 3-Acetyl-2,6-Difluorophenylboronic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay (HPLC), purity, and impurity profiles. Our quality commitment aligns with the standards expected by the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.