Description

3-Acetyl-6-Bromo-2-Fluorophenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound matters as a critical building block in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the fluorine and bromine substituents for enhanced bioactivity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and OFETs.
• Ligand and Catalyst Development: Employed in the design of novel bidentate ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized for bioconjugation and the synthesis of molecular probes for target identification and validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions.

Basic Information

Product Name	3-Acetyl-6-Bromo-2-Fluorophenylboronic Acid
CAS No.	1451390-80-9
Molecular Formula	C8H7BBrFO3
Molecular Weight	259.86 g/mol
Synonyms	(3-Acetyl-6-bromo-2-fluorophenyl)boronic acid; 2-Fluoro-6-bromo-3-acetylbenzeneboronic acid; 3-Acetyl-2-fluoro-6-bromobenzeneboronic acid; Boronic acid, B-(3-acetyl-6-bromo-2-fluorophenyl)-; 1451390-80-9; 3-Acetyl-6-bromo-2-fluorophenyl-B(OH)2
EINECS	Contact for details

Quality Control

Every batch of 3-Acetyl-6-Bromo-2-Fluorophenylboronic Acid undergoes rigorous analytical testing to ensure it meets the stringent purity requirements for advanced synthetic applications. Our quality assurance protocols are aligned with ICH guidelines, and we provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and MS. We support development and commercial projects requiring compliance with cGMP, ISO 9001, and REACH regulations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.