Description

Cbznh-Peg4-Ch2Cooh CAS NO 1451362-51-8 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a carboxylic acid (COOH) terminal group, designed for advanced bioconjugation and linker applications. This compound is critical for creating stable, water-soluble conjugates in pharmaceutical research and development, enabling precise attachment of active molecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, proteomics, and diagnostic reagent development who require reliable and customizable linker chemistry.

Application

• Bioconjugation Linker: Used as a heterobifunctional crosslinker for coupling peptides, proteins, or antibodies to other molecules, nanoparticles, or solid surfaces.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key component in the synthesis of linkers for ADCs, connecting cytotoxic drugs to monoclonal antibodies.
• PEGylation Reagent: Employed to introduce carboxylic acid functionality for further modification in the PEGylation of therapeutic proteins to enhance solubility and stability.
• Diagnostic Probe Synthesis: Facilitates the attachment of fluorescent dyes, biotin, or other reporter molecules to targeting agents for in vitro diagnostics (IVD).
• Polymer Chemistry: Acts as a macromonomer or building block for synthesizing functionalized, biocompatible polymers and hydrogels.
• Material Surface Functionalization: Used to modify the surface of nanomaterials (e.g., gold nanoparticles, quantum dots) with carboxyl groups for subsequent biomolecule immobilization.

Basic Information

Product Name	Cbznh-Peg4-Ch2Cooh
CAS No.	1451362-51-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	CBZ-NH-PEG4-CH2COOH; Fmoc-N-amido-PEG4-acid; Carboxy-PEG4-Cbz-amine; N-[(Benzyloxy)carbonyl]-3,6,9,12-tetraoxapentadecan-15-oic acid; 15-[(Benzyloxy)carbonyl]amino-4,7,10,13-tetraoxapentadecanoic acid; Cbz-NH-PEG4-acid; Z-NH-PEG4-CH2CO2H; N-Carbobenzoxy-15-amino-4,7,10,13-tetraoxapentadecanoic acid
EINECS	Contact for details

Quality Control

Our Cbznh-Peg4-Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.