Description

Vismodegib-D4 is a deuterated isotopologue of the Hedgehog signaling pathway inhibitor Vismodegib, specifically labeled with four deuterium atoms. This stable isotope-labeled compound is a critical reference standard and internal standard for quantitative bioanalytical studies, ensuring accuracy and reliability in pharmacokinetic and metabolic research. It is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions conducting advanced drug metabolism and mass spectrometry-based assays.

Application

• Internal Standard for LC-MS/MS: Primary use as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the precise measurement of Vismodegib in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of the parent drug's absorption, distribution, metabolism, and excretion (ADME) profile in preclinical and clinical studies.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing, validating, and ensuring the regulatory compliance of bioanalytical methods (e.g., following FDA/EMA guidelines).
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex biological samples.
• Stability-Indicating Assays: Used in studies to assess the chemical stability of Vismodegib under various storage and physiological conditions.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for drug substance and product quality control in GMP environments.

Basic Information

Product Name	Vismodegib-D4
CAS No.	1450990-33-6
Molecular Formula	C19H10D4Cl2N2O3S
Molecular Weight	409.31 g/mol (for deuterated form)
Synonyms	2-Chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl-d3)benzamide; GDC-0449-d4; Erivedge-d4; 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-[(methyl-d3)sulfonyl]benzamide; Vismodegib (tetradeuterated); Hedgehog pathway inhibitor-d4; Vismodegib internal standard
EINECS	Contact for details

Quality Control

Our Vismodegib-D4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic purity (D-enrichment), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for reference materials to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.