Description

n-Boc-5-Methylpyrrolidine-2,4-Dione is a high-purity, protected heterocyclic building block of significant value in advanced organic synthesis. This compound serves as a versatile intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those containing pyrrolidine or succinimide motifs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce functionalized heterocyclic scaffolds.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the scalable synthesis of target molecules under GMP or non-GMP conditions.
• Agrochemical Synthesis: Employed in the development of novel pesticides and herbicides that require specific heterocyclic cores for bioactivity.
• Academic & Contract Research: Utilized in universities and CROs for methodological development and the exploration of new chemical spaces.
• Custom Synthesis & Building Blocks: Supplied to fine chemical companies for the production of tailored intermediates for their client projects.

Basic Information

Product Name	n-Boc-5-Methylpyrrolidine-2,4-Dione
CAS No.	1450828-51-9
Molecular Formula	C10H15NO4
Molecular Weight	213.23 g/mol
Synonyms	1-tert-Butyl 5-methyl 2,4-dioxopyrrolidine-1,5-dicarboxylate; 5-Methyl-1,5-dioxopyrrolidine-1-carboxylic acid tert-butyl ester; tert-Butyl 5-methyl-2,4-dioxo-1-pyrrolidinecarboxylate; Boc-5-Methyl-2,4-pyrrolidinedione; N-Boc-5-Methyl-2,4-dioxopyrrolidine; 5-Methyl-N-Boc-2,4-pyrrolidinedione; Boc-protected 5-methylpyrrolidine-2,4-dione
EINECS	Contact for details

Quality Control

Our n-Boc-5-Methylpyrrolidine-2,4-Dione is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.