Description

Glp-1(7-37)Acetate is a synthetic peptide analog of the naturally occurring glucagon-like peptide-1, modified with an acetate salt form to enhance stability and handling. This compound is of significant interest for its role in metabolic research and as a critical intermediate in the development of therapeutic agents targeting type 2 diabetes and obesity. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on endocrinology and drug discovery.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of GLP-1 receptor agonists.
• Metabolic Disease Studies: Used in in vitro and in vivo research to investigate insulin secretion, glucose homeostasis, and appetite regulation mechanisms.
• Bioconjugation & Formulation Studies: Acts as a substrate for developing long-acting peptide conjugates or novel drug delivery systems.
• Quality Control & Analytical Testing: Employed as a high-purity standard in HPLC, LC-MS, and other analytical methods for method validation and batch testing.
• Preclinical Evaluation: Utilized in animal model studies to assess the efficacy and pharmacokinetics of next-generation anti-diabetic therapies.

Basic Information

Product Name	Glp-1(7-37)Acetate
CAS No.	1450806-98-0
Molecular Formula	C149H226N40O47 • xC2H4O2
Molecular Weight	~3358.7 g/mol (free base)
Synonyms	GLP-1 (7-37) acetate salt; Glucagon-like peptide 1 (7-37) acetate; GLP-1 fragment 7-37 acetate; H-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2 acetate; Liraglutide intermediate; Exendin-4 related peptide; Incretin mimetic peptide acetate
EINECS	Contact for details

Quality Control

Our Glp-1(7-37)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and tests for residual solvents and related substances. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring traceability and compliance with research-grade standards. Custom synthesis to meet specific purity or grade requirements (e.g., >95%, >98%) is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For optimal stability, store under inert atmosphere after opening.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Peptide Content (UV)	≥ 80.0%
Acetate Content (IC)	3.0 - 8.0%
Water Content (KF)	≤ 5.0%
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.