Description

(4S)-Fmoc-4-Phenoxy-D-Proline is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing conformational constraints and specific functional groups into peptide chains, enabling the development of novel therapeutics and research tools. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on peptide-based drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the Fmoc-strategy synthesis of complex peptides, particularly where a rigid proline scaffold with a phenoxy side chain is required.
• Peptidomimetic Drug Development: Used to create constrained peptide analogs with enhanced metabolic stability, bioavailability, and target specificity for therapeutic applications.
• Chemical Biology Probes: Incorporation into peptide sequences to study protein-protein interactions, enzyme mechanisms, and cellular signaling pathways.
• Libraries for High-Throughput Screening: Serves as a valuable component in the generation of diverse peptide libraries for screening against biological targets.
• Research on Collagen Mimetics: The proline derivative structure makes it useful in synthesizing peptides that mimic collagen-like triple helices.

Basic Information

Product Name	(4S)-Fmoc-4-Phenoxy-D-Proline
CAS No.	1449693-84-8
Molecular Formula	C26H23NO5
Molecular Weight	429.46 g/mol
Synonyms	Fmoc-D-Pro(4-PhO)-OH; (4S)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-phenoxy-D-proline; D-4-Phenoxyproline, N-Fmoc derivative; Fmoc-4-phenoxy-D-proline; N-α-Fmoc-4-phenoxy-D-proline; (2S,4S)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-phenoxypyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (4S)-Fmoc-4-Phenoxy-D-Proline is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material traceability documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.