Description

(3-Fluoro-4-(4-Oxopiperidin-1-Yl)Phenyl)Boronic Acid Pinacol Ester is a high-value, advanced pharmaceutical intermediate belonging to the class of protected boronic acid derivatives. This compound is essential for facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug molecules, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl halides and boronic acids, critical for creating diverse chemical libraries for high-throughput screening.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of organic electronic materials, such as polymers for OLEDs or sensors.
• Chemical Biology Probe Synthesis: Employed to create tagged molecules for studying biological pathways and protein interactions.
• Process Chemistry & Scale-up: Supports the transition from laboratory-scale discovery to pilot and commercial manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(3-Fluoro-4-(4-Oxopiperidin-1-Yl)Phenyl)Boronic Acid Pinacol Ester
CAS No.	1449144-86-8
Molecular Formula	C₁₇H₂₃BFNO₃
Molecular Weight	319.18 g/mol
Synonyms	1-[2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidin-4-one; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-1-(4-oxopiperidin-1-yl)benzene; (3-Fluoro-4-(4-oxo-1-piperidinyl)phenyl)boronic acid pinacol ester; 2-(3-Fluoro-4-(4-oxopiperidin-1-yl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[3-fluoro-4-(4-oxo-1-piperidinyl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our (3-Fluoro-4-(4-Oxopiperidin-1-Yl)Phenyl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.