Description

5-(n-Boc-Amino)-2-Fluorophenylboronic Acid, Pinacol Ester is a high-purity, protected boronic ester building block designed for advanced organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly in the construction of complex pharmaceutical intermediates. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate Synthesis: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl scaffolds found in drug candidates.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the modular synthesis of linkers and warheads for targeted protein degradation molecules.
• Agrochemical Research: Employed in creating novel active ingredients with specific biological activity through selective coupling.
• Material Science: Serves as a building block for functionalized polymers and organic electronic materials requiring precise fluorine and boronate ester functionality.
• Chemical Biology & Bioconjugation: Facilitates the site-specific labeling and modification of biomolecules due to its orthogonal reactivity and protected amine.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis of diverse compound libraries for screening against biological targets.

Basic Information

Product Name	5-(n-Boc-Amino)-2-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	1449135-41-4
Molecular Formula	C17H25BFNO4
Molecular Weight	337.20 g/mol
Synonyms	5-[(tert-Butoxycarbonyl)amino]-2-fluorobenzeneboronic acid pinacol ester; 2-Fluoro-5-[(2-methyl-2-propanyloxy)carbonyl]amino]benzeneboronic acid pinacol ester; N-Boc-3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl carbamic acid tert-butyl ester; 5-(Boc-amino)-2-fluorophenylboronic acid pinacol ester; Boc-Protected 2-fluoro-5-boronophenylalanine pinacol ester precursor
EINECS	Contact for details

Quality Control

Our 5-(n-Boc-Amino)-2-Fluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.