Description

3-Fluoro-4-(2-Pyridylcarbamoyl)Benzeneboronic Acid is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its unique molecular architecture, combining a boronic acid moiety with a pyridylcarbamoyl group, making it a critical reagent for constructing complex molecules via cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boronic acid coupling partner for creating biaryl and heterobiaryl structures central to modern medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: A precursor for synthesizing organic electronic materials, such as those used in OLEDs and sensors.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for synthetic methodology development and discovery chemistry in academic and CRO laboratories.

Basic Information

Product Name	3-Fluoro-4-(2-Pyridylcarbamoyl)Benzeneboronic Acid
CAS No.	1449133-22-5
Molecular Formula	C₁₂H₁₀BFN₂O₃
Molecular Weight	260.03 g/mol
Synonyms	3-Fluoro-4-[(pyridin-2-yl)carbamoyl]benzeneboronic acid; 4-Borono-2-fluoro-N-(pyridin-2-yl)benzamide; 2-Fluoro-4-(2-pyridinylaminocarbonyl)benzeneboronic acid; (3-Fluoro-4-((pyridin-2-yl)carbamoyl)phenyl)boronic acid; B-[3-Fluoro-4-[(2-pyridinylamino)carbonyl]phenyl]boronic acid; 1449133-22-5; 3-Fluoro-4-(pyridine-2-carboxamido)phenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(2-Pyridylcarbamoyl)Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.