Description

3-Fluoro-4-(4-Methylpiperidine-1-Carbonyl)Phenylboronic Acid is a sophisticated boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a fluorinated, piperidine-carbonyl substituted aromatic system, enabling the construction of complex molecular architectures. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, due to the 4-methylpiperidine moiety.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic acid functional group makes it an ideal coupling partner for constructing biaryl and heterobiaryl systems prevalent in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require fluorinated aromatic compounds for enhanced bioactivity and environmental stability.
• Material Science: Serves as a monomer or functionalization agent in the creation of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and affinity ligands for studying protein function and interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Fluoro-4-(4-Methylpiperidine-1-Carbonyl)Phenylboronic Acid
CAS No.	1449132-53-9
Molecular Formula	C13H17BFNO3
Molecular Weight	265.09 g/mol
Synonyms	[3-Fluoro-4-(4-methyl-1-piperidylcarbonyl)phenyl]boronic acid; (3-Fluoro-4-((4-methylpiperidin-1-yl)carbonyl)phenyl)boronic acid; 3-Fluoro-4-(4-methylpiperidine-1-carbonyl)benzeneboronic acid; B-[3-Fluoro-4-[(4-methyl-1-piperidinyl)carbonyl]phenyl]boronic acid; 1449132-53-9; AKOS026710293; 4-(4-Methylpiperidine-1-carbonyl)-3-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(4-Methylpiperidine-1-Carbonyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.