Description

tert-Butyl (3R)-3-(Pyrimidin-4-Ylamino)Pyrrolidine-1-Carboxylate is a high-purity chiral building block and Boc-protected intermediate of significant value in modern synthetic chemistry. Its core value lies in providing a stereochemically defined pyrrolidine scaffold, which is essential for constructing complex molecules with specific biological activity. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibition and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel bioactive molecules.
• Agrochemical Synthesis: Serves as a building block for developing advanced crop protection agents with specific modes of action.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) during clinical development phases.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for clients.

Basic Information

Product Name	tert-Butyl (3R)-3-(Pyrimidin-4-Ylamino)Pyrrolidine-1-Carboxylate
CAS No.	1448850-55-2
Molecular Formula	C13H20N4O2
Molecular Weight	264.33 g/mol
Synonyms	1-Boc-3R-[(pyrimidin-4-yl)amino]pyrrolidine; (R)-tert-Butyl 3-(pyrimidin-4-ylamino)pyrrolidine-1-carboxylate; (3R)-1-(tert-Butoxycarbonyl)-3-(pyrimidin-4-ylamino)pyrrolidine; tert-Butyl (R)-3-(pyrimidin-4-ylamino)pyrrolidine-1-carboxylate; 1-Boc-3-((pyrimidin-4-yl)amino)-(R)-pyrrolidine; (R)-1-Boc-3-(4-pyrimidylamino)pyrrolidine; 1448850-55-2; Pyrrolidine-1-carboxylic acid, 3-[(4-pyrimidinyl)amino]-, 1,1-dimethylethyl ester, (3R)-
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R)-3-(Pyrimidin-4-Ylamino)Pyrrolidine-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to industry-standard analytical methods, including HPLC, NMR, and MS, to verify identity and quality. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.