Description

Eleclazine (Hydrochloride) CAS NO 1448754-43-5 is a high-purity, small-molecule pharmaceutical intermediate and research chemical. This compound is of significant interest for its role in the development of novel cardiac and neurological therapeutics, specifically as a late sodium current inhibitor. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic research institutions focused on ion channel modulation.

Application

• Pharmaceutical Research & Development: Key intermediate in the synthesis of novel drug candidates targeting cardiac arrhythmias.
• Preclinical Studies: Used in vitro and in vivo models to investigate late sodium current (INaL) blockade for conditions like long QT syndrome and atrial fibrillation.
• Biochemical Assay Development: Serves as a reference standard and active agent in high-throughput screening (HTS) for ion channel activity.
• Mechanism of Action (MoA) Studies: Critical tool for elucidating the pharmacological profile and selectivity of sodium channel modulators.
• Academic Research: Employed in university labs for fundamental studies on cardiac electrophysiology and channelopathies.
• GMP Manufacturing: Sourced as a starting material or intermediate for cGMP production of active pharmaceutical ingredients (APIs) under stringent quality protocols.

Basic Information

Product Name	Eleclazine (Hydrochloride)
CAS No.	1448754-43-5
Molecular Formula	C₂₀H₂₅ClN₂O₃ • HCl
Molecular Weight	397.34 g/mol (for hydrochloride salt)
Synonyms	GS-6615; GS6615; Eleclazine HCl; 4-[[(3S,5R)-3,5-Dimethyl-1-piperazinyl]methyl]-N-[4-(1-methylethyl)phenyl]-2-benzothiazolamine hydrochloride; (S,R)-GS-6615 hydrochloride; Late Sodium Current Inhibitor GS-6615
EINECS	Contact for details

Quality Control

Our Eleclazine (Hydrochloride) is manufactured and tested under a rigorous quality management system. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS. We support development with GMP-grade material upon request, ensuring traceability and documentation for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.