Description

Um171 CAS NO 1448724-09-1 is a potent and selective small molecule agonist of the aryl hydrocarbon receptor (AhR), widely recognized for its role in hematopoietic stem cell (HSC) expansion. This compound is crucial for research and development in regenerative medicine and cell therapy, offering a powerful tool for *ex vivo* stem cell culture. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic research institutions focused on hematopoiesis, immunology, and advanced therapeutic medicinal product (ATMP) development.

Application

• Hematopoietic Stem Cell (HSC) Expansion: Key component in defined media for the *ex vivo* expansion of human cord blood and bone marrow-derived HSCs.
• Regenerative Medicine Research: Used in studies aimed at improving engraftment and reconstitution potential of stem cells for transplantation therapies.
• Immunology and Disease Modeling: Employed to investigate AhR pathway signaling in immune cell differentiation, function, and in modeling related diseases.
• Drug Discovery & Screening: Serves as a reference compound and positive control in high-throughput screens for novel AhR modulators.
• Cell Therapy Process Development: Integral to optimizing manufacturing protocols for cell-based therapies, enhancing yield and potency.
• Academic & Preclinical Research: Fundamental research tool for understanding stem cell biology, niche interactions, and lineage commitment.

Basic Information

Item	Details
Product Name	Um171
CAS No.	1448724-09-1
Molecular Formula	C₂₀H₁₅N₅O₂
Molecular Weight	357.37 g/mol
Synonyms	UM 171; UM-171; 2-Pyridinecarboxamide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(1H-pyrrol-1-yl)-; AhR agonist UM171; StemRegenin 1 analog; Hematopoietic stem cell expansion compound; 5-(1H-Pyrrol-1-yl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)picolinamide
EINECS	Contact for details

Quality Control

Our Um171 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, potency, and full specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.