Description

(R)-(+)-2,2'-Bis[Di(3,5-Dimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. Its core value proposition lies in enabling highly enantioselective transformations, which are critical for the efficient and cost-effective synthesis of single-enantiomer pharmaceutical intermediates and fine chemicals. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in their synthetic routes.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in API synthesis.
• Pharmaceutical Intermediate Manufacturing: Critical for constructing chiral centers in complex drug molecules, including cardiovascular, antiviral, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Asymmetric C-C Bond Formation: Facilitates key cross-coupling and addition reactions with high stereoselectivity.
• Process Chemistry & Scale-up: Employed in the development and optimization of commercial-scale manufacturing processes for chiral compounds.
• Academic & Industrial R&D: A valuable tool for methodological development and exploring new asymmetric catalytic cycles.

Basic Information

Product Name	(R)-(+)-2,2'-Bis[Di(3,5-Dimethoxyphenyl)Phosphino]-6,6'-Dimethoxy-1,1'-Biphenyl
CAS No.	1448722-98-2
Molecular Formula	C52H52O10P2
Molecular Weight	898.91 g/mol
Synonyms	(R)-DTBM-SEGPHOS; (R)-3,5-(t-Bu)2-4-MeO-SEGPHOS; (R)-DTBM-Segphos; (R)-5,5'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole; (R)-2,2'-Bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4',6,6'-tetramethyl-1,1'-biphenyl (common misassignment, correct for related ligand); (R)-DTBM-SEGPHOS Ligand; SEGPHOS Derivative; Chiral Bisphosphine Ligand.
EINECS	Contact for details

Quality Control

Every batch of our (R)-DTBM-SEGPHOS is manufactured and tested under strict quality management systems to ensure exceptional purity and chiral integrity, critical for reproducible catalytic performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and metal content. Our quality commitment aligns with the standards required for cGMP and advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.