Description

Fmoc-Dap(Bromoacetyl)-Oh CAS NO 1448613-98-6 is a specialized, protected amino acid derivative designed for advanced peptide synthesis. This compound is a critical building block for the site-specific introduction of reactive bromoacetyl groups into peptide chains, enabling precise bioconjugation and labeling strategies. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating antibody-drug conjugates (ADCs), peptide-based therapeutics, and diagnostic probes.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: A key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide-Based Drug Development: Enables the site-specific functionalization of therapeutic peptides for enhanced targeting, stability, or pharmacokinetic properties.
• Bioconjugation and Protein Labeling: Used to attach fluorophores, affinity tags (like biotin), or other molecules to peptides and proteins for diagnostic and research applications.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected, Fmoc-compatible amino acid building block for the automated synthesis of complex, modified peptides.
• Chemical Biology Tool Development: Facilitates the creation of activity-based probes and other chemical tools for studying enzyme function and protein-protein interactions.
• Material Science and Surface Modification: Can be used to functionalize surfaces or polymers with bioactive peptide sequences for tissue engineering or biosensor applications.

Basic Information

Product Name	Fmoc-Dap(Bromoacetyl)-Oh
CAS No.	1448613-98-6
Molecular Formula	C₂₂H₂₁BrN₂O₆
Molecular Weight	489.32 g/mol
Synonyms	Fmoc-L-Dap(Bromoacetyl)-OH; Nα-Fmoc-Nβ-(bromoacetyl)-L-2,3-diaminopropionic acid; Fmoc-Dap(BrAc)-OH; (2S)-3-[[(2-Bromoacetyl)amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid; Fmoc-3-amino-L-alanine(Bromoacetyl); N-Fmoc-N'-(bromoacetyl)-L-diaminopropionic Acid; Fmoc-Dap(Bromoacetyl)-OH DCHA salt (when applicable); Protected bromoacetyl diaminopropionic acid derivative
EINECS	Contact for details

Quality Control

Our Fmoc-Dap(Bromoacetyl)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (Titration)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.