Description

(2S,4R)-tert-Butyl 4-Hydroxy-2-((4-(4-Methylthiazol-5-Yl)Benzyl)Carbamoyl)Pyrrolidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex stereochemistry and a heterocyclic thiazole moiety. This compound is critical for research and development in targeted drug discovery, particularly in the synthesis of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing small molecule inhibitors and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its defined stereochemistry and functional groups.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component (ligand or linker) in the design of bifunctional molecules for targeted protein degradation.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Custom Synthesis: Sourced by fine chemical suppliers for custom synthesis projects requiring high-stereochemical purity and complex molecular architecture.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis and drug discovery projects.

Basic Information

Product Name	(2S,4R)-tert-Butyl 4-Hydroxy-2-((4-(4-Methylthiazol-5-Yl)Benzyl)Carbamoyl)Pyrrolidine-1-Carboxylate
CAS No.	1448191-54-5
Molecular Formula	C22H29N3O4S
Molecular Weight	431.55 g/mol
Synonyms	1-Boc-4-hydroxy-2-[(4-(4-methyl-5-thiazolyl)benzyl)carbamoyl]pyrrolidine; (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide; tert-Butyl (2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carboxylate; UNII-8V3Q5C6Y1C; 8V3Q5C6Y1C; BOC-Hydroxy-Proline-(4-Methylthiazole-Benzyl)amide; (2S,4R)-1-Boc-4-hydroxy-pyrrolidine-2-carboxylic acid [4-(4-methyl-thiazol-5-yl)-benzyl]-amide
EINECS	Contact for details

Quality Control

Our (2S,4R)-tert-Butyl 4-Hydroxy-2-((4-(4-Methylthiazol-5-Yl)Benzyl)Carbamoyl)Pyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to confirm stereochemical purity, NMR for structural confirmation, and LC-MS for identity and purity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.