Description

2,6-Difluoro-3-Iodophenylboronic Acid is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules. Its unique halogenated and fluorinated structure offers strategic sites for further functionalization, making it a versatile intermediate in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine and iodine substituents for enhanced biological activity and stability.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as charge-transport layers, OLED emitters, and liquid crystals, where the difluoro-iodo-phenyl core influences optoelectronic properties.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic acid coupling partner to form biaryl and heterobiaryl bonds, a fundamental reaction in medicinal and process chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Catalyst Ligand Development: Acts as a starting material for synthesizing sophisticated ligand systems used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	2,6-Difluoro-3-Iodophenylboronic Acid
CAS No.	1447827-58-8
Molecular Formula	C6H4BF2IO2
Molecular Weight	283.81 g/mol
Synonyms	(2,6-Difluoro-3-iodophenyl)boronic acid; 3-Iodo-2,6-difluorophenylboronic acid; 2,6-Difluoro-3-iodobenzeneboronic acid; Boronic acid, B-(2,6-difluoro-3-iodophenyl)-; 1447827-58-8; 2,6-Difluoro-m-iodophenylboronic Acid
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-3-Iodophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and ICP-MS for heavy metal screening, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full analytical data are provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals (ICP-MS)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.