Description

2'-o-Allylcytidine is a chemically modified nucleoside derivative, specifically a cytidine analog with an allyl group at the 2'-oxygen position of the ribose sugar. This modification is crucial for its role as a key synthetic intermediate and building block in advanced oligonucleotide chemistry, particularly in the development of antisense oligonucleotides and siRNA therapeutics. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of novel nucleic acid-based drugs and diagnostic probes. The compound offers researchers a versatile handle for further functionalization, enabling precise control over the properties of the final oligonucleotide construct.

Application

• Pharmaceutical Intermediate: A critical building block for the solid-phase synthesis of therapeutic oligonucleotides, including antisense drugs and siRNA.
• Antiviral Drug Research: Used in the development and study of nucleoside analogs targeting viral polymerases.
• Pro-drug Synthesis: Serves as a precursor for creating more bioavailable or targeted forms of cytidine-based therapeutics.
• Bioconjugation & Labeling: The allyl group provides a reactive site for attaching fluorescent dyes, affinity tags, or other functional moieties to oligonucleotides.
• Academic & Industrial R&D: Employed in fundamental research to study RNA structure, function, and stability, as well as in developing novel nucleic acid tools.
• Diagnostic Probe Development: Used in the manufacture of specialized probes for genetic testing and molecular diagnostics.

Basic Information

Product Name	2'-o-Allylcytidine
CAS No.	1446115-19-0
Molecular Formula	C12H17N3O5
Molecular Weight	283.28 g/mol
Synonyms	2'-O-Allylcytidine; 1-[(2R,3R,4R,5R)-3-Allyloxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-aminopyrimidin-2-one; Cytidine, 2'-O-allyl-; 4-Amino-1-((2R,3R,4R,5R)-3-(allyloxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; Allyl Cytidine Derivative; 2'-O-allyl-Cytidine; 2'-O-Allylcytidine (Cytidine 2'-O-allyl ether)
EINECS	Contact for details

Quality Control

Our 2'-o-Allylcytidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive pharmaceutical R&D applications. We adhere to current industry standards for fine chemical production. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity and purity. A Certificate of Analysis (COA) detailing all relevant specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.