Description

Dspe-Peg-Nhs is a heterobifunctional polyethylene glycol (PEG) derivative featuring a DSPE phospholipid anchor and an NHS ester terminus. This compound is a critical reagent for creating stealth liposomes and targeted drug delivery systems by enabling the covalent conjugation of amine-containing ligands to lipid surfaces. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced nanomedicines, diagnostic agents, and long-circulating liposomal formulations.

Application

• Stealth Liposome (PEGylated Liposome) Preparation: Conjugation of PEG chains to lipid bilayers to impart steric stabilization, reduce opsonization, and prolong blood circulation time.
• Targeted Drug Delivery Systems: Functionalization of liposomes with targeting ligands (e.g., antibodies, peptides, folates) via the NHS ester group for site-specific therapeutic delivery.
• Nanoparticle Surface Modification: PEGylation of lipid-based nanoparticles (LNPs), micelles, and other nanocarriers to improve biocompatibility and pharmacokinetic profiles.
• Diagnostic Agent Conjugation: Attachment of imaging probes or contrast agents to lipid structures for diagnostic applications.
• Bioconjugation & Crosslinking: A versatile crosslinker for coupling amine-bearing biomolecules to phospholipid membranes in model studies or biosensor development.
• Biomimetic Membrane Research: Incorporation into artificial membranes to study the effects of PEGylation on membrane properties and protein interactions.

Basic Information

Product Name	Dspe-Peg-Nhs
CAS No.	1445723-73-8
Molecular Formula	CnH2n+1NOmP (Variable based on PEG chain length)
Molecular Weight	Variable (Depends on PEG chain length, e.g., 2000, 3400, 5000 Da). Contact for details.
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[succinimidyl(polyethylene glycol)]; DSPE-PEG-NHS Ester; DSPE-PEGn-NHS; NHS-PEG-DSPE; Phospholipid-PEG-NHS; Succinimidyl ester of DSPE-PEG; PEGylated DSPE-NHS; Amine-reactive PEG-DSPE
EINECS	Contact for details.

Quality Control

Our Dspe-Peg-Nhs is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and performance for critical research and cGMP-grade applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White or off-white solid/waxy solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95%
Functional Group Substitution (NHS Ester)	≥90%
Water Content (KF)	≤1.0%
Solubility	Soluble in chloroform, DMSO, DMF; partially soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.