Description

5-Ethoxy-2,3-Difluorophenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is a protected boronic acid derivative, offering enhanced stability and handling characteristics for complex cross-coupling reactions. It is a critical building block for researchers and manufacturers in the pharmaceutical and agrochemical industries, enabling the synthesis of novel fluorinated and ethoxy-substituted aromatic frameworks. Its primary utility lies in Suzuki-Miyaura coupling, a cornerstone methodology for carbon-carbon bond formation.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl and ethoxy motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, where the fluorine atoms can improve lipophilicity and biological activity.
• Material Science Research: Serves as a monomer or building block for creating novel organic electronic materials, such as OLEDs and semiconductors, via polymerization or functionalization.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis and Contract Manufacturing: An essential reagent for fine chemical and custom synthesis houses serving the global life sciences market.

Basic Information

Product Name	5-Ethoxy-2,3-Difluorophenylboronic Acid, Pinacol Ester
CAS No.	1445601-61-5
Molecular Formula	C14H19BF2O3
Molecular Weight	284.11 g/mol
Synonyms	5-Ethoxy-2,3-difluorophenylboronic acid pinacol ester; 2,3-Difluoro-5-ethoxyphenylboronic acid pinacol ester; (5-Ethoxy-2,3-difluorophenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(5-ethoxy-2,3-difluorophenyl)-1,3,2-dioxaborolane; 5-Ethoxy-2,3-difluorophenyl-Bpin; Boronic acid, B-(5-ethoxy-2,3-difluorophenyl)-, 1,1-dimethylethyl ester (9CI); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 5-Ethoxy-2,3-Difluorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (1H, 13C, 19F, 11B) and HPLC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.