Description

2-[4-Methoxy-3-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester, critical for modern synthetic chemistry. Its core value lies in enabling efficient and selective carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced material development. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and methoxy substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that leverage its unique aromatic substitution pattern.
• Material Science: Serves as a precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Research & Development: A versatile reagent for academic and industrial research in medicinal chemistry and synthetic methodology development.
• Liquid Crystal & Polymer Chemistry: Used to incorporate specific aromatic motifs into advanced polymers and liquid crystal molecules for tailored properties.

Basic Information

Item	Information
Product Name	2-[4-Methoxy-3-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1445019-24-8
Molecular Formula	C14H18BF3O3
Molecular Weight	302.10 g/mol
Synonyms	4-Methoxy-3-(trifluoromethyl)phenylboronic acid pinacol ester; [4-Methoxy-3-(trifluoromethyl)phenyl]boronic acid pinacol ester; 2-(4-Methoxy-3-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Trifluoromethyl-4-methoxyphenylboronic acid pinacol ester; Pinacol [4-methoxy-3-(trifluoromethyl)phenyl]boronate; 4-Methoxy-α,α,α-trifluoro-m-tolylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-[4-Methoxy-3-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening containers to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.