Description

Methyl 5-(4-Fluorophenyl)-3-Methyl-5-Oxovalerate is a high-purity fluorinated ketoester intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring both a fluorinated aromatic ring and a reactive ketoester moiety, makes it a versatile building block for constructing complex molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides where the fluorine atom enhances bioactivity and environmental stability.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials requiring fluorinated components for specific thermal or chemical resistance properties.
• Organic Synthesis & Process Chemistry: Serves as a versatile electrophile or Michael acceptor in multi-step synthetic routes for complex molecule construction in laboratory and pilot-scale settings.
• Ligand and Catalyst Development: Intermediate for synthesizing fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Methyl 5-(4-Fluorophenyl)-3-Methyl-5-Oxovalerate
CAS No.	1443306-85-1
Molecular Formula	C13H15FO3
Molecular Weight	238.26 g/mol
Synonyms	5-(4-Fluorophenyl)-3-methyl-5-oxopentanoic acid methyl ester; Methyl 5-(4-fluorobenzoyl)-3-methylbutyrate; 3-Methyl-5-oxo-5-(4-fluorophenyl)pentanoic acid methyl ester; 4-Fluorophenyl 3-methyl-5-oxovalerate methyl ester; Methyl 3-methyl-5-oxo-5-(4-fluorophenyl)valerate; 1443306-85-1; MFCD30129012
EINECS	Contact for details

Quality Control

Our production of Methyl 5-(4-Fluorophenyl)-3-Methyl-5-Oxovalerate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality system supports development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.