Description

Eleclazine is a high-purity pharmaceutical intermediate and research chemical with significant therapeutic potential. This compound is of critical importance for the development of novel treatments targeting cardiac arrhythmias and other ion channel-related disorders. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for preclinical and clinical-stage development programs.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel cardiac antiarrhythmic agents.
• Ion Channel Modulator Studies: Used in biochemical and electrophysiological research to study late sodium current (INaL) inhibition.
• Preclinical Drug Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Contract Manufacturing: Supplied to CDMOs for the scale-up and GMP production of investigational new drugs.
• Reference Standard: Utilized as an analytical standard for quality control and method validation in API manufacturing.
• Academic Research: Employed in university and institutional labs for cardiovascular disease mechanism studies.

Basic Information

Product Name	Eleclazine
CAS No.	1443211-72-0
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	GS-6615; GS6615; 4-[[(2S,4R)-5-(4-Bromophenyl)-2-(ethoxymethyl)-4-methyl-6-oxo-3,4-dihydro-1H-pyrimidin-1-yl]methyl]benzonitrile; Eleclazine (GS-6615); (2S,4R)-1-[(4-Cyanophenyl)methyl]-5-(4-bromophenyl)-2-(ethoxymethyl)-4-methyl-1,4-dihydro-6-pyrimidinone
EINECS	Contact for details

Quality Control

Our Eleclazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.