Description

trans-3-Fluoro-4-Hydroxy-Tetrahydropyran is a high-value fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound is prized for its unique stereochemistry and the presence of both fluorine and hydroxyl functional groups on the tetrahydropyran ring, which are critical for modulating the physicochemical and biological properties of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the construction of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or modifier for creating specialty polymers with tailored properties.
• Fluorine Chemistry Research: An important substrate for studying fluorination reactions and the stereoelectronic effects of fluorine in cyclic ether systems.

Basic Information

Product Name	trans-3-Fluoro-4-Hydroxy-Tetrahydropyran
CAS No.	1443112-12-6
Molecular Formula	C5H9FO2
Molecular Weight	120.12 g/mol
Synonyms	(3R,4S)-3-Fluoro-4-hydroxytetrahydropyran; (3S,4R)-3-Fluoro-4-hydroxytetrahydropyran; 3-Fluoro-4-hydroxytetrahydropyran (trans); trans-4-Hydroxy-3-fluorotetrahydropyran; 3-Fluoro-tetrahydropyran-4-ol; THP Fluorohydrin Derivative; Fluorinated Tetrahydropyranol; 1443112-12-6
EINECS	Contact for details

Quality Control

Our trans-3-Fluoro-4-Hydroxy-Tetrahydropyran is manufactured under strict quality control protocols to ensure high chemical purity and stereochemical integrity, suitable for demanding R&D and scale-up applications. We provide comprehensive analytical data including chiral HPLC to confirm enantiomeric excess. A detailed Certificate of Analysis (COA) with batch-specific results for identity, purity, and related substances is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e. (trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.