Description

(4S,5R,6R,7S,8R)-5-(Acetylamino)-2,6-Anhydro-4-Azido-3,4,5-Trideoxy-7-o-Methyl-D-Glycero-D-Galacto-Non-2-Enonic Acid Methyl Ester Cyclic 8,9-Carbonate is a sophisticated, high-purity carbohydrate derivative and a key chiral building block in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel pharmaceuticals, particularly in the synthesis of complex nucleoside analogs and antiviral agents. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for constructing intricate molecular scaffolds with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of antiviral drugs, including neuraminidase inhibitors and other nucleoside-based therapeutics.
• Antiviral Agent Synthesis: Serves as a key precursor in the synthesis of complex carbohydrate mimetics that target viral enzymes and replication mechanisms.
• Glycochemistry Research: Used in academic and industrial research to study glycosylation reactions, carbohydrate-protein interactions, and to develop new glycosidase inhibitors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds targeting infectious diseases.
• Process Chemistry Development: Utilized for scaling up synthetic routes to active pharmaceutical ingredients (APIs) requiring this specific stereochemically-defined carbohydrate core.
• Bioconjugation & Probe Development: The reactive azido group enables click chemistry applications for labeling, imaging, and developing targeted bioconjugates.

Basic Information

Item	Detail
Product Name	(4S,5R,6R,7S,8R)-5-(Acetylamino)-2,6-Anhydro-4-Azido-3,4,5-Trideoxy-7-o-Methyl-D-Glycero-D-Galacto-Non-2-Enonic Acid Methyl Ester Cyclic 8,9-Carbonate
CAS No.	1442873-91-7
Molecular Formula	C13H17N5O8
Molecular Weight	371.31 g/mol
Synonyms	Methyl (4S,5R,6R,7S,8R)-5-acetamido-2,6-anhydro-4-azido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonate 8,9-carbonate; 5-Acetamido-4-azido-2,6-anhydro-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid methyl ester 8,9-carbonate; Zanamivir Intermediate Derivative; Neuraminidase Inhibitor Intermediate; Cyclic Carbonate Protected Sialic Acid Derivative; 4-Azido-5-acetamido Sialic Acid Methyl Ester Carbonate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ state-of-the-art analytical techniques, including HPLC, NMR, and MS, to verify the compound's identity, chiral purity, and conformity to client specifications. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. The compound is moisture-sensitive and should be handled under dry conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.