Description

2-Oxazoleacetonitrile, 4-(1,1-Dimethylethyl)-α-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-4,5-Dihydro-, (4R)- is a high-value, stereochemically defined chiral building block. This compound is critical for the synthesis of complex molecules, offering precise control over molecular architecture in advanced chemical processes. It is primarily sought after by pharmaceutical R&D and fine chemical manufacturers for applications in asymmetric synthesis and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for complex small-molecule drugs.
• Asymmetric Synthesis: Utilized as a sophisticated ligand precursor or building block in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Agrochemical Research: Employed in the synthesis of novel, high-efficacy crop protection agents with specific stereochemical requirements.
• Material Science: Serves as a precursor for advanced functional materials, such as liquid crystals or specialty polymers, where its rigid, substituted oxazole structure is beneficial.
• Academic & Industrial R&D: Used in chemical research laboratories for methodological development and exploring new reaction pathways in heterocyclic chemistry.

Basic Information

Item	Details
Product Name	2-Oxazoleacetonitrile, 4-(1,1-Dimethylethyl)-α-[(4R)-4-(1,1-Dimethylethyl)-4,5-Dihydro-2-Oxazolyl]-4,5-Dihydro-, (4R)-
CAS No.	1442644-13-4
Molecular Formula	C16H25N3O2
Molecular Weight	291.39 g/mol
Synonyms	(4R)-4-tert-Butyl-α-[(4R)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]-4,5-dihydro-1,3-oxazole-2-acetonitrile; (4R)-α-[(4R)-4-(tert-Butyl)-4,5-dihydro-2-oxazolyl]-4-(tert-butyl)-4,5-dihydro-2-oxazoleacetonitrile; 4-tert-Butyl-α-[(4R)-4-tert-butyl-4,5-dihydro-2-oxazolyl]-4,5-dihydro-2-oxazoleacetonitrile, (4R)-; Chiral Oxazole Nitrile Building Block
EINECS	Contact for details

Quality Control

Every batch of our 2-Oxazoleacetonitrile derivative is produced under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC and NMR spectroscopy, to ensure exceptional enantiomeric purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with each shipment to guarantee reliable performance in your sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.