Description

3-Piperidinepropanoic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Oxo-, Methyl Ester, (αs,3S)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate (API) crucial for modern drug discovery. This compound serves as a sophisticated building block for synthesizing complex molecules, enabling the development of targeted therapeutics with enhanced efficacy and specificity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and protease inhibitors due to its piperidine and protected amino acid ester functionalities.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in early-stage drug discovery programs.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of proprietary compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and organic chemistry.

Basic Information

Product Name	3-Piperidinepropanoic Acid, α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Oxo-, Methyl Ester, (αs,3S)-
CAS No.	1442483-69-3
Molecular Formula	C15H26N2O5
Molecular Weight	314.38 g/mol
Synonyms	(3S)-3-[[(tert-Butoxycarbonyl)amino]-2-oxo-3-piperidinepropanoic acid methyl ester; Methyl (3S)-3-[(tert-butoxycarbonyl)amino]-2-oxo-3-piperidinepropanoate; Boc-L-3,4-dehydro-2-piperidineglycine methyl ester (stereoisomer); (αS,3S)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-oxo-3-piperidinepropanoic acid methyl ester; tert-Butyl ((3S)-1-(2-methoxy-2-oxoethyl)-6-oxo-1,2,3,6-tetrahydropyridin-3-yl)carbamate; Advanced Chiral Piperidine Intermediate
EINECS	Contact for details

Quality Control

Our 3-Piperidinepropanoic Acid derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.