Description

L-Valinamide, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-2-Methylalanyl-n-[(1S,2S)-1-[(1R)-2-Carboxy-1-Methoxyethyl]-2-Methylbutyl]-n-Methyl- is a sophisticated, non-natural amino acid derivative designed for advanced pharmaceutical research and development. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering researchers precise control over molecular structure and bioactivity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel therapeutic candidates, including protease inhibitors and other targeted biologics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of complex peptide-based drug candidates.
• Protease Inhibitor Development: Used to construct specific pharmacophores in the research and development of inhibitors for enzymes like HCV protease, renin, and HIV protease.
• Peptidomimetic Engineering: Serves as a backbone-modified amino acid residue to enhance metabolic stability, bioavailability, and binding affinity of peptide therapeutics.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and enzyme mechanisms.
• Process Chemistry & Scale-Up: Used in the development and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs) under cGMP conditions.
• Custom Peptide Synthesis: A specialized monomer for the custom synthesis of research-grade and pre-clinical peptide sequences by CROs and CDMOs.

Basic Information

Product Name	L-Valinamide, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-2-Methylalanyl-n-[(1S,2S)-1-[(1R)-2-Carboxy-1-Methoxyethyl]-2-Methylbutyl]-n-Methyl-
CAS No.	1438851-55-8
Molecular Formula	C34H45N3O8
Molecular Weight	623.74 g/mol
Synonyms	Fmoc-L-Valinamide derivative; (2S)-2-[[(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-methylbutanoyl]-methylamino]-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-3-methylbutanamide; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methylalanyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-L-valinamide; Advanced peptide building block; Fmoc-protected valine analog; Chiral amino acid intermediate.
EINECS	Contact for details

Quality Control

This high-purity building block is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request. Our production adheres to standards suitable for pharmaceutical R&D, supporting work under ISO and cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.