Description

1-(Benzyloxy)-2-Fluoro-3-(Trifluoromethoxy)Benzene is a high-value fluorinated aromatic ether building block. This compound is engineered to introduce multiple fluorine-containing functional groups, which are critical for modulating the physicochemical properties of advanced materials and active pharmaceutical ingredients. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecules with enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for introducing trifluoromethoxy and fluoro substituents.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine motifs improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed as a monomer or modifier to develop specialty polymers with unique solubility, thermal stability, and surface properties.
• Chemical Research: A versatile building block in medicinal chemistry and material science for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	1-(Benzyloxy)-2-Fluoro-3-(Trifluoromethoxy)Benzene
CAS No.	1437794-77-8
Molecular Formula	C14H10F4O2
Molecular Weight	286.22 g/mol
Synonyms	1-(Benzyloxy)-2-fluoro-3-(trifluoromethoxy)benzene; 2-Fluoro-3-(trifluoromethoxy)phenyl benzyl ether; Benzene, 1-(benzyloxy)-2-fluoro-3-(trifluoromethoxy)-; 1-(Benzyloxy)-2-fluoro-3-(trifluoromethoxy)benzene (CAS 1437794-77-8); 2-Fluoro-α-(trifluoromethoxy)benzylbenzene; Fluorinated Benzyloxy Benzene Derivative
EINECS	Contact for details

Quality Control

Our 1-(Benzyloxy)-2-Fluoro-3-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.