Description

Rilpivirine n-Glucuronide is a crucial metabolite of the non-nucleoside reverse transcriptase inhibitor (NNRTI) Rilpivirine. This compound is of significant importance for pharmaceutical research and development, particularly in the fields of drug metabolism and pharmacokinetics (DMPK) studies. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in bioanalytical method development, metabolite identification, and regulatory safety assessments.

Application

• Reference Standard for Bioanalysis: Serves as a certified standard for the quantitative and qualitative analysis of Rilpivirine metabolites in biological matrices (plasma, urine) using LC-MS/MS and HPLC methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and pharmacokinetic profile of Rilpivirine.
• Metabolite Safety and Toxicology Testing: Used as an analytical standard to assess the potential toxicity and safety profile of the glucuronidated metabolite.
• Pharmaceutical Impurity Profiling: Acts as a known impurity or degradation product reference in the quality control of Rilpivirine active pharmaceutical ingredient (API) and finished drug products.
• Enzymatic Reaction Studies: Utilized in in vitro studies to understand the activity of UDP-glucuronosyltransferase (UGT) enzymes involved in its formation.
• Regulatory Submission Support: Provides critical data for regulatory filings (e.g., with the FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolic fate.

Basic Information

Product Name	Rilpivirine n-Glucuronide
CAS No.	1437791-52-0
Molecular Formula	C33H35N5O8
Molecular Weight	629.66 g/mol
Synonyms	4-[[4-[[4-[(E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]pyrimidin-2-yl]amino]benzonitrile β-D-Glucopyranosiduronic Acid; Rilpivirine Glucuronide; Rilpivirine N-Glucuronide; TMC278 Glucuronide; RPV Glucuronide; 1-(4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)phenyl)-1-deoxy-β-D-glucopyranuronic Acid
EINECS	Contact for details

Quality Control

Our Rilpivirine n-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.