Description

2-Fluoro-4-Nitrophenylboronic Acid is a high-purity boronic acid derivative, a key building block in modern synthetic chemistry. Its value lies in its dual functionality, where the boronic acid group enables Suzuki-Miyaura cross-coupling reactions, and the nitro and fluoro substituents offer versatile sites for further chemical modification. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing complex drug candidates, particularly in the development of kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its structural motifs for biological activity.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a key coupling partner (boronic acid component) in palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and sensors for studying biological processes.
• Organic Synthesis Scaffold: The nitro group provides a handle for reduction to amines, and the fluorine allows for selective substitution, making it a versatile scaffold for library synthesis.

Basic Information

Product Name	2-Fluoro-4-Nitrophenylboronic Acid
CAS No.	1436608-93-3
Molecular Formula	C6H5BFNO4
Molecular Weight	184.92 g/mol
Synonyms	(2-Fluoro-4-nitrophenyl)boronic Acid; 2-Fluoro-4-nitrobenzeneboronic Acid; B-(2-Fluoro-4-nitrophenyl)boronic Acid; 4-Nitro-2-fluorophenylboronic Acid; 2-Fluoro-4-nitrophenyl-Boronic Acid; 2-Fluoro-4-nitrobenzeneboronic acid; 1436608-93-3; 2-Fluoro-4-nitrophenylboronic acid pinacol ester (common derivative)
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Nitrophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.